Driving Innovation: Our R&D Platforms and Services

Five platforms, endless solutions — from targeted services to full-scale bioprocess development based on synthetic biology and precision fermentation.

Explore the capabilities of our technological platforms to boost your development.

Explore the capabilities of our technological platforms to boost your development.

Plataformas y servicios

The Synthetic Biology platform designs and genetically optimizes microorganisms (bacteria and yeast), integrating Molecular Biology, Metabolic Engineering, and Microbiology techniques. It also provides plasmid and strain construction services for external clients and companies within the Bioceres Group. The platform is equipped with specialized technology for the manipulation and analysis of genetic material, ensuring precision and efficiency in every development.

  • High flexibility for the construction of plasmids and custom DNA molecules.
  • Genomic and plasmid DNA extraction.
  • Gene editing (mutagenesis, deletions, and insertions) in model microorganisms. Ask us about editing systems for non-model species.
  • Microorganism transformation: Escherichia coli, Bacillus subtilis, Pichia pastoris, Agrobacterium tumefaciens. Ask us about other species.
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Our fermentation platform includes four bioreactors: two 2-liter, one 5-liter, and one 250-milliliter unit, allowing us to run parallel fermentations and speed up process optimization. All systems are equipped with temperature control and monitoring capabilities for pH, foam level, and dissolved oxygen. We offer both batch and fed-batch fermentations, with controlled feeding via peristaltic pumps and automated feeding programs. Additionally, we integrate metabolomics techniques for process characterization, supported by a fully equipped microbiology lab.

  • Execution of fermentation processes based on client-provided protocols.
  • Development and/or optimization of microbial fermentation processes for the production of biomolecules, inoculants, and more.
  • Evaluation of potential raw materials for use as components of fermentation media.
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The Protein Technology platform collaborates in R&D projects with clients aiming to develop new biological products using recombinant microorganisms. We specialize in the production of recombinant proteins in GRAS organisms (Generally Recognized As Safe by the FDA), such as Bacillus subtilis y Pichia pastorisogether with INMET's other platforms, we support the entire process—from strain design and construction to production, scaling, and purification—ensuring efficiency and high performance at every stage.

  • Protein engineering.
  • Structural analysis / Homology modeling.
  • Recombinant protein production.
  • Protein purification using chromatographic columns.
  • Protein sample characterization.
  • Protein quantification.
  • Protein profiling and purity analysis via polyacrylamide gel densitometry.
  • Protein identification by immunodetection.
  • Enzymatic characterization.
  • Quantification of enzymatic activities.
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INMET’s pilot plant provides tailored solutions for clients seeking to optimize microbial fermentation processes. With a team of engineers, biotechnologists, and technicians specialized in scale-up and biomolecule purification, we operate 500- and 1000-liter fermenters to transform innovations into efficient production processes. Beyond scale-up, we also offer small-scale production of biomolecules that do not require industrial volumes—such as enzymes for the baking industry, among others.

We operate 500 L and 1,000 L stirred-tank bioreactors for fermentation scale-up.

  • System type: Stirred-tank with automated control of critical parameters such as temperature, pH, and antifoam levels.
  • Operation: Suitable for microbial cultures under aseptic conditions.
  • Modes: Batch and fed-batch processes.
  • Real-time monitoring and data logging of key process variables including temperature, pressure, pH, and dissolved oxygen (DO).

Cell separation and clarification using a GEA pilot-scale disc-stack centrifugeos piloto GEA

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At INMET, we develop bioprocesses based on microbial fermentation, using Metabolic Engineering to optimize the production of high-value bioproducts. To support this, we apply Mass Spectrometry to assess the metabolic state of microorganisms and quantify key metabolites. We also provide technical consulting and analytical method development for clients from the private sector, public institutions, and companies within the Bioceres Holding group.

We operate a gas chromatograph coupled to a mass spectrometer (GC-MS), a high-precision tool for identifying, quantifying, and analyzing volatile and semi-volatile organic compounds in complex mixtures.

  • Quali-quantitative analysis of volatile and semi-volatile compounds in essential oils and spices.
  • Determination of bacterial lipid profiles (sterols, fatty acids).
  • Detection of aliphatic, aromatic, polycyclic aromatic hydrocarbons (PAHs), and FAMEs.
  • Identification of volatile organic compounds via Headspace GC-MS.
  • Development of customized analytical methods.

LC-MS/MS combines liquid chromatography and mass spectrometry to detect, identify, and quantify organic compounds in complex matrices with high precision.

  • Pre-analysis service: solid-phase extraction (C18/silica columns), liquid-liquid extractions with solvents, filtration, inert N₂ gas drying and/or lyophilization of various matrices prior to analysis.
  • Direct infusions of pure compounds using syringe pump.
  • Secondary metabolite profiling in plant extracts, e.g., phenolic compounds.
  • Determination of bacterial fermentation products using HPLC-UV-IR.
  • Quantification of carbon sources (sugars/alcohols) in culture media using HPLC-IR (Refractive Index Detector).
  • Quantification of intracellular bacterial metabolites, e.g., CoA pools, phosphorylated metabolic intermediates.
  • Molecular weight determination of synthetic/natural polymers via Gel Permeation Chromatography (GPC) using chloroform as the mobile phase. Includes calculation of Polydispersity Index (PDI) and average molecular weights by weight (Mw) and by number (Mn).
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Strategic R&D Focus: Tailored Solutions Through Synthetic Biology and Precision Fermentation.

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Personalized Evaluation

We analyze your needs and assess the feasibility of the project.

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Iterative Development

We implement continuous improvements through genomic and metabolomic analysis, incorporating precise changes into our biological models.

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Proof of Concept

We validate the functionality and efficiency of the development under controlled conditions.

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Scale-Up and Production

We scale the process to pilot level, maintaining quality and optimizing costs.

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Contact us for more information and guidance.

Advanced R&D and Technology Services

+54 3413163587

Biomaterials

[email protected]

General Inquiries

[email protected]

Address

Ocampo 210 bis, Predio CCT Rosario (2000) Rosario, Santa Fe, Argentina

Desarrollado por Grupo Vansur | Copyright © 2025 INMET

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